ARA-290 10 mg

ARA-290, also known as cibinetide, is a synthetic 11-amino-acid peptide derived from the helix-B (tissue-protective) domain of erythropoietin (EPO). It was engineered to reproduce the tissue-protective and anti-inflammatory signaling associated with EPO while omitting the hormone's erythropoietic (red-blood-cell-stimulating) activity. As a short, non-hematopoietic EPO analog, it belongs to the class of tissue-repair and innate-repair-receptor-targeting peptides and is supplied here as a research reagent.

In preclinical and in-vitro research, ARA-290 has been investigated as an agonist of the innate repair receptor, a heteromeric complex thought to comprise the erythropoietin receptor and the beta-common receptor that is selectively upregulated in injured or inflamed tissue. Within these experimental models, investigators have examined its role in modulating inflammatory signaling, supporting cellular and tissue protection, and influencing nerve-related endpoints. Reported study contexts include animal and cell-based models of neuropathy, neuroinflammation, ischemic and metabolic tissue injury, and cardiac inflammation, where researchers have measured outcomes such as nerve fiber density and markers of inflammatory response. All such findings derive from laboratory and animal studies and are presented solely as research observations, not as established effects in humans.

Specifications: CAS 1208243-50-8 · Molecular formula C51H84N16O21 · Molecular weight 1257.3 g/mol · Sequence/length 11 amino acids (pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser) · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes Default

Storage & handling: Store the lyophilized powder at -20C and protect it from light. Reconstitute with bacteriostatic (BAC) water for laboratory preparation. Keep the reconstituted solution refrigerated and use it within a few weeks to preserve peptide integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.