Cagrilintide

Cagrilintide is a long-acting synthetic amylin analog, a 37-amino-acid peptide whose backbone is derived from the human amylin analog pramlintide (itself based on human amylin / islet amyloid polypeptide). Its sequence incorporates several amino-acid substitutions and an intramolecular disulfide bridge between two cysteine residues, together with a lipidation (fatty-acid acylation) modification that promotes reversible binding to serum albumin. This acylation chemistry is the principal feature that distinguishes it from native amylin, markedly extending its circulating half-life in research models and giving rise to its characterization as a long-acting amylin analog.

In preclinical and in-vitro studies, Cagrilintide has been investigated as a non-selective amylin receptor agonist, with reported activity at the calcitonin receptor and the RAMP-containing amylin receptor complexes (the AMY1, AMY2, and AMY3 subtypes). It has been used as a tool compound to study satiety signaling, energy homeostasis, and body-weight regulation, with animal-model research pointing to hindbrain regions such as the area postrema and nucleus of the solitary tract as relevant sites of activity. Investigations have also examined its co-administration with incretin-class peptides in research settings exploring metabolic pathways.

These descriptions reflect findings from laboratory, in-vitro, and animal research only and are provided to characterize the compound for scientific investigation. They are not statements of efficacy or safety in humans.

Specifications: CAS 1415456-99-3 · Molecular formula C194H312N54O59S2 · Molecular weight approximately 4409.0 g/mol · Sequence/length 37 amino acids (with an intramolecular disulfide bridge) · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes 10 mg, 5 mg

Storage & handling: Store the lyophilized powder at -20C and protect from light. Reconstitute with bacteriostatic (BAC) water; keep the reconstituted solution refrigerated and use within a few weeks. Avoid repeated freeze-thaw cycles to preserve peptide integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.