CJC1295 Without DAC

CJC-1295 Without DAC, also known as Modified GRF (1-29) or Mod GRF 1-29, is a synthetic peptide belonging to the class of growth hormone-releasing hormone (GHRH) analogs. It is derived from the first 29 amino acids of endogenous human GHRH, the bioactive N-terminal fragment that retains the receptor-binding activity of the full 44-residue parent hormone. This research analog incorporates several amino-acid substitutions intended to improve resistance to enzymatic degradation and oxidation relative to the native sequence. Unlike the DAC (Drug Affinity Complex) conjugated version, this "without DAC" form lacks the maleimidopropionic acid moiety used to bind serum albumin, and is characterized in the literature by a comparatively short circulating profile.

In preclinical and in-vitro studies, CJC-1295 Without DAC has been investigated for its interaction with the GHRH receptor on pituitary somatotroph cells, where binding is reported to activate adenylate cyclase and elevate intracellular cAMP, a pathway associated with pulsatile growth hormone synthesis and secretion in animal models. Within research settings it has served as a tool compound for exploring the somatotropic axis, GHRH receptor signaling, and downstream effects on growth-hormone and IGF-1 dynamics. Reported observations from such models include effects on tissue repair, body-composition parameters, and metabolic signaling, all studied strictly in laboratory and animal contexts rather than clinical use.

Specifications: CAS 863288-34-0 · Molecular formula C152H252N44O42 · Molecular weight 3367.9 g/mol · Sequence/length 29 amino acids (Modified GRF 1-29) · PubChem CID 56841945 · Form lyophilized powder · Available sizes 10 mg, 5 mg

Storage and handling: Store the lyophilized powder at -20C and protect from light. Reconstitute with bacteriostatic (BAC) water for laboratory preparation. Keep the reconstituted solution refrigerated and use within a few weeks to maintain peptide integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.