Follistatin 344 1 mg

Follistatin-344 (FST-344) is a recombinant glycoprotein corresponding to the 344-amino-acid precursor isoform of follistatin, a secreted autocrine/paracrine protein encoded by the FST gene (UniProt P19883). It is generated by alternative splicing of the follistatin precursor mRNA and, following cleavage of its 29-residue signal peptide, yields a mature secreted protein of approximately 315 amino acids. Biochemically, follistatin belongs to the class of activin-binding proteins and functions as a high-affinity antagonist of several TGF-beta superfamily ligands, most notably myostatin (GDF-8) and activin A.

In preclinical and in-vitro research, Follistatin-344 has been studied primarily for its role in the regulation of skeletal-muscle development through inhibition of the myostatin and activin signaling axis. Because myostatin acts as a negative regulator of muscle mass, animal-model and gene-transfer studies have investigated whether follistatin-mediated antagonism is associated with increased muscle fiber size and lean tissue accumulation. Reported preclinical work in rodent and nonhuman-primate models has examined follistatin in the context of muscle hypertrophy, muscular-dystrophy disease models, and fibrosis.

Additional laboratory investigations have explored follistatin's broader interactions within the TGF-beta superfamily, including its activin-binding activity and its observed effects on metabolic and tissue-remodeling pathways in cultured cells and animal systems. All such findings derive strictly from experimental research and are reported here only as observations from that literature.

Specifications: Identity Follistatin-344 (FST-344) recombinant follistatin isoform · Gene/UniProt FST / P19883 · Sequence/length 344-amino-acid precursor isoform (mature ~315 aa after cleavage of the 29-residue signal peptide) · Form lyophilized powder · Available sizes Default

Storage and handling: Store the lyophilized powder at -20C and protect it from light. Reconstitute with bacteriostatic (BAC) water for laboratory use. Keep the reconstituted solution refrigerated and use it within a few weeks to preserve integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.