KPV

KPV is a synthetic tripeptide composed of the amino acids lysine, proline, and valine (Lys-Pro-Val), corresponding to the C-terminal sequence (residues 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). As one of the smallest fragments retaining the biological signature of its parent hormone, KPV is widely used as a reference compound in studies of melanocortin-derived peptides. It is typically produced by solid-phase peptide synthesis and supplied as a lyophilized powder for laboratory characterization and in-vitro work.

In preclinical and in-vitro research, KPV has been investigated for its role in modulating inflammatory signaling pathways. Reported observations in cell-culture and animal models suggest that, unlike full-length alpha-MSH, KPV's activity in these systems does not appear to depend primarily on classical melanocortin receptors; instead, laboratory studies have described cellular uptake via the di/tripeptide transporter PepT1, allowing the peptide to interact with intracellular targets. Investigators have noted a relatively favorable stability profile and resistance to enzymatic degradation in experimental settings compared with the parent peptide.

Within rodent models of intestinal inflammation, peer-reviewed studies have examined KPV in the context of reduced colonic inflammation scores, lowered pro-inflammatory cytokine levels, and attenuated histological injury markers. These findings are reported strictly as outcomes of controlled laboratory research and are presented here to characterize the compound's documented research context, not to imply any effect in humans.

Specifications: CAS 67727-97-3 · Molecular formula C16H30N4O4 · Molecular weight 342.43 g/mol · Sequence/length Lys-Pro-Val, 3 amino acids · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes 10mg, 5mg

Storage & handling: Store the lyophilized powder at -20C and protect it from light. Reconstitute with bacteriostatic (BAC) water for laboratory use. Keep the reconstituted solution refrigerated and use it within a few weeks to maintain integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.