MGF 2 mg

MGF (Mechano Growth Factor) is a synthetic research peptide based on the unique C-terminal E-domain of the IGF-1Ec splice variant of insulin-like growth factor 1 (IGF-1). It belongs to the family of IGF-1-derived growth-factor peptides. In humans, a reading-frame shift in the IGF-1 gene under mechanical loading or tissue stress produces a distinct 24-amino-acid C-terminal extension (the "E peptide"), which is structurally separate from the mature IGF-1 receptor-binding domain. The peptide supplied here is the commonly studied 24-residue MGF E-peptide variant (C-terminal amide), which differs from the exact native human IGF-1Ec sequence by a single residue (histidine in place of arginine near the C-terminus) and is widely used in laboratory investigation.

In preclinical and in-vitro research, MGF and its synthetic E-peptide have been studied as a putative local signaling factor expressed in skeletal muscle in response to mechanical overload and damage. Published cell and animal studies have investigated its proposed role in activating muscle satellite (progenitor) cells, modulating myoblast proliferation and fusion, and influencing tissue repair and regeneration pathways. Researchers have also examined its activity in models of cardiac, neural, tenocyte, and bone biology. Findings across the literature are mixed: some studies report effects on progenitor-cell behavior, while others observed no apparent effect on myoblasts or primary muscle stem cells, underscoring that its mechanism remains an active area of investigation. All such observations are derived strictly from controlled laboratory, in-vitro, and animal models.

Specifications: Molecular formula C121H200N42O39 · Molecular weight ~2867.2 g/mol · Sequence H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2 · Length 24 amino acids · Purity >=98% (HPLC) · Form lyophilized powder · Available sizes Default

Storage & handling: Store the lyophilized powder at -20C and protect it from light and moisture. Reconstitute with bacteriostatic (BAC) water for laboratory use. Keep the reconstituted solution refrigerated at 2-8C and use it within a few weeks to limit peptide degradation. Avoid repeated freeze-thaw cycles.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.