P21 10 mg

P21, also referred to as P021 in the primary literature, is a small synthetic peptidomimetic derived from the most biologically active region of ciliary neurotrophic factor (CNTF), corresponding to residues 148-151. Its core is a four-amino-acid fragment (acetyl-Asp-Gly-Gly-Leu) that has been chemically modified, including an adamantylated glycine appended at the C-terminus, yielding the designation Ac-DGGLAG-NH2. This adamantane substitution was engineered to increase lipophilicity and metabolic stability and to reduce degradation by exopeptidases relative to the parent neurotrophic protein. P21 was developed by investigators at the New York State Institute for Basic Research in Developmental Disabilities as a low-molecular-weight CNTF mimetic intended for use as a research tool.

In preclinical and in-vitro research, P21 has been investigated for its role in neurogenesis, particularly the generation of new neurons in the hippocampus, a region associated with learning and memory in animal models. Studies in transgenic and aged rodent models have examined the compound for its reported effects on dendritic and synaptic markers, tau-related pathology, and CNTF-associated neurotrophic signaling pathways. These findings are observations from controlled laboratory and animal studies and do not establish any effect in humans.

Specifications: CAS 1246751-68-7 · Molecular formula C27H42N6O8 · Molecular weight 578.67 g/mol · Sequence Ac-DGGLAG-NH2 (CNTF 148-151-derived tetrapeptide core with adamantylated C-terminal glycine) · Purity >=99% (HPLC) · Form lyophilized powder · Size 10 mg

Storage and handling: store the lyophilized powder at -20C and protect it from light. Reconstitute with bacteriostatic (BAC) water for laboratory use; keep the reconstituted solution refrigerated and use it within a few weeks. Avoid repeated freeze-thaw cycles to preserve peptide integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.