PT-141 10 mg

PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide belonging to the melanocortin receptor ligand class. It is an analog of the alpha-melanocyte-stimulating hormone (alpha-MSH) family and is the major active metabolite of the earlier research peptide melanotan II, differing from it by a free C-terminal carboxyl group in place of a C-terminal amide. Its seven-amino-acid backbone carries the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, in which an intramolecular lactam bridge between aspartic acid and lysine side chains constrains the ring conformation and contributes to its receptor activity profile.

In preclinical research, PT-141 has been characterized as a non-selective melanocortin receptor agonist with notable activity at the melanocortin-4 (MC4R) and melanocortin-3 (MC3R) receptors. In vitro receptor-binding work and animal models have been used to investigate its central mechanism of action, including reported activation of hypothalamic neurons measured by increased c-Fos immunoreactivity in rodent and primate studies. Because MC3R and MC4R are widely expressed in central nervous system regions associated with arousal and motivation, this compound is frequently used as a research tool for probing melanocortin signaling pathways. Investigators studying reproductive and neuroendocrine physiology have examined PT-141 in laboratory settings to explore melanocortin-mediated signaling rather than to establish any therapeutic outcome. All effects described here derive from in-vitro and animal research and should not be interpreted as human health claims.

Specifications: CAS 189691-06-3 · Molecular formula C50H68N14O10 · Molecular weight 1025.2 g/mol · Sequence/length cyclic heptapeptide (7 amino acids), Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes Default

Storage & handling: Store the lyophilized powder at -20C and protect it from light. For laboratory use, reconstitute with bacteriostatic (BAC) water; keep the reconstituted solution refrigerated and use it within a few weeks.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.