Semax

Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) family. Its structure corresponds to the ACTH(4-7) melanocortin fragment (Met-Glu-His-Phe) extended at the C-terminus with a Pro-Gly-Pro sequence, giving a seven-amino-acid chain (Met-Glu-His-Phe-Pro-Gly-Pro). The terminal Pro-Gly-Pro motif was added to improve resistance to enzymatic degradation, and unlike native ACTH the molecule is reported to lack hormonal (corticotropic) activity. It was first developed in Russia in the 1980s as a research analog of ACTH(4-10).

In preclinical and in-vitro research, Semax has been investigated for its role in neurotrophic signaling and neuronal survival. Rodent studies have reported that administration is associated with increased expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and with phosphorylation of the TrkB receptor in the hippocampus and frontal cortex. Additional animal-model work has examined the peptide in the context of cerebral ischemia, where investigators have measured changes in infarct volume and markers of the post-ischemic inflammatory cascade.

Further laboratory studies have explored Semax in relation to dopaminergic and serotonergic neurotransmitter systems and broad transcriptional changes in brain tissue. These findings are observations from controlled preclinical and in-vitro experiments and are reported here solely to characterize the compound for laboratory research.

Specifications: CAS 80714-61-0 · Molecular formula C37H51N9O10S · Molecular weight 813.9 g/mol · Sequence Met-Glu-His-Phe-Pro-Gly-Pro (7 amino acids) · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes 10mg, 5mg

Storage & handling: Store the lyophilized powder at -20C and protect from light. Reconstitute with bacteriostatic (BAC) water; keep the reconstituted solution refrigerated and use within a few weeks.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.