Sermorelin + Ipamorelin Blend

Sermorelin + Ipamorelin Blend is a combination of two synthetic peptides studied as growth hormone secretagogues acting through distinct, complementary receptor pathways. Sermorelin is a 29-amino-acid polypeptide corresponding to the 1-29 fragment of endogenous human growth hormone-releasing hormone (GHRH), the shortest fully functional fragment of GHRH, and behaves as a GHRH-receptor agonist. Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) incorporating non-standard residues such as aminoisobutyric acid and D-2-naphthylalanine; it is a selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R). Because the two compounds engage separate receptor systems, the blend is frequently used in research models to probe the interaction of the GHRH and ghrelin signaling axes.

In preclinical and in-vitro studies, GHRH analogues such as sermorelin have been investigated for their role in stimulating pulsatile growth hormone release from pituitary somatotrophs, while ipamorelin has been examined as a selective secretagogue reported to elevate growth hormone levels in animal models with comparatively low effect on other pituitary hormones. The research rationale for combining them is to study potential additive or synergistic modulation of the somatotropic axis, body-composition endpoints, and downstream IGF-1 signaling in laboratory systems. These observations derive strictly from animal and cell-based research and have not been established as human outcomes.

Specifications (Sermorelin): CAS 86168-78-7 · Molecular formula C149H246N44O42S · Molecular weight 3357.93 g/mol · Sequence/length 29 amino acids (GHRH 1-29) · Synonyms GRF 1-29, GHRH 1-29 amide · Form lyophilized powder. Specifications (Ipamorelin): CAS 170851-70-4 · Molecular formula C38H49N9O5 · Molecular weight 711.9 g/mol · Sequence/length pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) · Synonym NNC 26-0161 · Form lyophilized powder · Purity >=99% (HPLC) · Available sizes Default

Storage & handling: store the lyophilized blend at -20C and protect from light. Reconstitute with bacteriostatic (BAC) water for laboratory preparation, keep the reconstituted solution refrigerated, and use within a few weeks. Avoid repeated freeze-thaw cycles.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.