Thymosin Alpha-1

Thymosin Alpha-1 (thymalfasin) is a 28-amino-acid, N-terminally acetylated peptide that belongs to the thymosin family of immunomodulatory peptides. It corresponds to a fragment derived by proteolytic processing of the larger precursor protein prothymosin alpha, and it was originally isolated from thymic tissue, where related peptides are associated with the maturation and regulation of immune cells. Its defined sequence (Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH) and acidic character make it a frequently referenced subject in peptide chemistry and biological research.

In preclinical and in-vitro studies, Thymosin Alpha-1 has been investigated for its role in modulating immune signaling. Reported research observations describe interactions with pattern-recognition receptors such as toll-like receptors (TLR2 and TLR9) and effects on dendritic cells, T-lymphocyte populations, and natural killer cell activity in laboratory models. Experimental literature has also examined its influence on cytokine profiles, antigen presentation, and immune-cell differentiation in cell-based and animal systems.

Additional preclinical work has explored Thymosin Alpha-1 as a tool compound for studying immune regulation and tolerance, as well as its behavior in oncology- and infection-focused experimental models. All such findings are reported strictly as observations from non-clinical research and are not statements of human efficacy or safety.

Specifications: CAS 62304-98-7 · Molecular formula C129H215N33O55 · Molecular weight ~3108.3 g/mol · Sequence/length 28 amino acids (N-terminally acetylated) · Synonyms Thymalfasin, Thymosin α1, Tα1 · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes 10mg, 5mg

Storage & handling: Store the lyophilized powder at -20C and protect it from light. For laboratory preparation, reconstitute with bacteriostatic (BAC) water; keep the reconstituted solution refrigerated and use it within a few weeks. Avoid repeated freeze-thaw cycles to preserve peptide integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.