VIP

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide belonging to the secretin/glucagon superfamily of regulatory peptides. First isolated from intestinal tissue, it is now known to be expressed broadly across the central and peripheral nervous systems, the gastrointestinal tract, and immune tissues. The peptide is C-terminally amidated and adopts a largely disordered conformation in aqueous solution, transitioning toward a stabilized alpha-helix upon membrane association or binding to its class B G-protein-coupled receptors (VPAC1 and VPAC2). This material is supplied as a synthetic, research-grade lyophilized peptide intended solely for in-vitro and laboratory investigation.

In preclinical and in-vitro research, VIP has been studied extensively as a signaling molecule in the nervous and immune systems. Investigators have examined its role in circadian timing within the suprachiasmatic nucleus, modulation of hippocampal NMDA-receptor activity and synaptic transmission, and its contribution to anti-inflammatory and immunomodulatory pathways in cellular and animal models. Within the cognitive and neuroscience research context, laboratory studies have explored VIP and its lipophilic derivatives for observed effects on neuronal survival and protection against beta-amyloid-associated toxicity in cultured neurons. These reports describe observations made strictly in experimental systems and do not establish any effect in humans.

Specifications: CAS 40077-57-4 · Molecular formula C147H238N44O42S · Molecular weight ~3325.8 g/mol · Sequence/length 28 amino acids (octacosapeptide, C-terminally amidated) · Purity >=99% (HPLC) · Form lyophilized powder · Available sizes 10mg, 5mg

Storage & handling: Store the lyophilized powder at -20C and protect it from light. For laboratory use, reconstitute with bacteriostatic (BAC) water; keep the reconstituted solution refrigerated and use it within a few weeks. Avoid repeated freeze-thaw cycles to preserve peptide integrity.

For research use only. Not for human consumption. This product is not a drug, food, or dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.